原著論文

2022年

1. Nishimoto-Kusunose S, Sawa M, Inaba Y, Ushiyama A, Ishii K, Hattori K, Ogasawara Y
Exposure to aerosol extract from heated tobacco products causes a drastic decrease of glutathione and protein carbonylation in human lung epithelial cells
Biochem. Biophys. Res. Commun., 589, 92-99, (2022)

2021年

1. Ohkubo T, Matsumoto Y, Cho O, Ogasawara Y, Sugita T
Delftia acidovorans secretes substances that inhibit the growth of Staphylococcus epidermidis through TCA cycle-triggered ROS production. PloS one 16(7) e0253618 (2021)

2. Koike S, Toriumi K, Kasahara S, Kibune Y, Ishida YI, Dan T, Miyata T, Arai M, Ogasawara Y
Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits. Antioxidants (Basel, Switzerland) 10(4):574 (2021)

3. Sawa M, Ushiyama A, Inaba Y, Uchiyama S, Hattori K, Ogasawara Y, Ishii K
A newly developed aerosol exposure apparatus for heated tobacco products for in vivo experiments can deliver both particles and gas phase with high recovery and depicts the time-dependent variation in nicotine metabolites in mouse urine. Nicotine Tob Res. 23(12):2145-2152. (2021)

4. Sugiura K*, Koike S*, Suzuki T, Ogasawara Y
Carbonylation of skin collagen induced by reaction with methylglyoxal. Biochem Biophys Res Commun. 2021 562:100-104. (2021) (*equal contribution)

5. Koike S, Miyaji Y, Sano H, Aikawa N, Kai M, Kasahara S, Suzuki T, Nishimoto-Kusunose S, Ogasawara Y
Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer's Disease in Mouse Brain and Plasma. Anal Sci. 37(8):1165-1170. (2021)

6. Koike S, Tanaka Y, Morishita Y, Ishibashi K
Effects of osmolality on the expression of brain aquaporins in AQP11-null mice. Biochimie. 188:2-6 (2021)

7. Toriumi K, Berto S, Koike S, Usui N, Dan T, Suzuki K, Miyashita M, Horiuchi Y, Yoshikawa A, Asakura M, Nagahama K, Lin HC, Sugaya Y, Watanabe T, Kano M, Ogasawara Y, Miyata T, Itokawa M, Konopka G, Arai M
Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex. Redox biology 45 102057 (2021)

2020年

1. Togashi K, Suzuki S, Morita S, Ogasawara Y, Imamura Y, Shin Y
Excessively activated plasminogen in human plasma cleaves VWF multimers and reduces collagen-binding activity. J Biochem. 168, 355-363. (2020)

2. Sugiura K, Koike S, Suzuki T, Ogasawara Y
Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage. Biol Pharm Bull., 43, 879-883 (2020)

3. Ohkubo T, Matsumoto Y, Cho O, Ogasawara Y, Sugita T
Complete Genome Sequence of Citrobacter koseri Strain MPUCK001. Microbiology resource announcements 9(50).(2020)

2019年

1. Ishida YI, Ichinowatari Y, Nishimoto S, Koike S, Ishii K, Ogasawara Y
Differential oxidation processes of peroxiredoxin 2 dependent on the reaction with several peroxides in human red blood cells. Biochem. Biophys. Res. Commun., 518, 685-690 (2019)

2. Fukano K, Tsukuda S, b Oshima M, Suzuki R, Aizaki H, Ohki M, Park SY, Muramatsu M, Wakita T, Sureau C, Ogasawara Y, Watashi K
Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes. Front. Microbiol., 9, 3257 (2019)

3. Koike S, Ando C, Usui Y, Kibune Y, Nishimoto S, Suzuki T, Ogasawara Y
Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain. Brain Res. Bull., 144, 164-170 (2019)

2018年

1. Nagahara N, Koike S, Nirasawa T, Kimura H, Ogasawara Y.
Alternative pathway of H2S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase. Biochem Biophys Res Commun. 496, 648-653 (2018)

2. Ikeda R, Ichikawa T, Tsukiji YK, Kawamura K, Kikuchi A, Ishida YI, Ogasawara Y
Identification of Heparin-binding Proteins on the Cell Surface of Cryptococcus neoformans. Med. Mycol. J., 59, E47-E52 (2018)

3. Passioura T, Watashi K, Fukano K, Shimura S, Saso W, Morishita R, Ogasawara Y, Tanaka Y, Mizokami M, Sureau C, Suga H, Wakita T
De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry. Cell Chem Biol., 25, 906-915 (2018)

2017年

1. Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi JS, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T.
Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity. J Hepatol. 66, 685-692 (2017)

2. Hanaoka K, Sasakura K, Suwanai Y, Toma-Fukai S, Shimamoto K, Takano Y, Shibuya N, Terai T, Komatsu T, Ueno T, Ogasawara Y, Tsuchiya Y, Watanabe Y, Kimura H, Wang C, Uchiyama M, Kojima H, Okabe T, Urano Y, Shimizu T, Nagano T.
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 7, 40227 (2017)

3. Miyamoto R, Koike S, Takano Y, Shibuya N, Kimura Y, Hanaoka K, Urano Y, Ogasawara Y, Kimura H.
Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels. Sci Rep. 7, 45995 (2017)

4. Nishimoto S, Koike S, Inoue N, Suzuki T, Ogasawara Y.
Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism. Biochem Biophys Res Commun. 483, 874-879 (2017)

5. Koike S, Nishimoto S, Ogasawara Y.
Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation. Redox Biol. 12, 530-539 (2017)

6. Ishida YI, Aki M, Fujiwara S, Nagahama M, Ogasawara Y.
Peroxidatic cysteine residue of peroxiredoxin 2 separated from human red blood cells treated by tert-butyl hydroperoxide is hyperoxidized into sulfinic and sulfonic acids.
Hum Cell. (2017)

7. Ikeda R, Ogasawara Y, Takatori K, Ichikawa T, Nakajima M, Harigaya K, Watanabe M, Okudaira E, Yoshikawa H, Yanagisawa K.
Growth Inhibition of an Opportunistic Yeast Pathogen Trichosporon asahii by Staphylococcus epidermidis. Biol Pharm Bull. 40, 693-697 (2017)

8. Fujihara K, Koike S, Ogasawara Y, Takahashi K, Koyama K, Kinoshita K.
Inhibition of amyloid β aggregation and protective effect on SH-SY5Y cells by triterpenoid saponins from the cactus Polaskia chichipe. Bioorg Med Chem. 25, 3377-3383 (2017)

9. Kimura Y, Koike S, Shibuya N, Lefer D, Ogasawara Y, Kimura H.
3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S. Sci Rep. 7, 10459 (2017)

10. Ishida Y.I, Kayama T, Kibune Y, Nishimoto S, Koike S, Suzuki T, Horiuchi Y, Miyashita M, Itokawa M, Arai M, Ogasawara Y.
Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress. Biochem Biophys Res Commun. 493, 573-577 (2017)

11. Koike S, Kawamura K, Kimura Y, Shibuya N, Kimura H, Ogasawara Y.
Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. Free Radic. Biol. Med. 113, 355-362 (2017)

2016年

1. Ogasawara Y, Tanaka R, Koike S, Horiuchi Y, Miyashita M, Arai M.
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1,2-diamino-4,5-methylenedioxybenzene. J Chromatogr B Analyt Technol Biomed Life Sci. 1029-1030, 102-105 (2016)

2. Koike S, Kayama T, Yamamoto S, Komine D, Tanaka R, Nishimoto S, Suzuki T, Kishida A, Ogasawara Y.
Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain. Neurotoxicology. 55, 13-19 (2016)

3. Koike S, Tanaka Y, Matsuzaki T, Morishita Y, Ishibashi K.
Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int. J. Mol. Sci. 17, 861 (2016)

4. Nishimoto S, Suzuki T, Koike S, Yuan B, Takagi N, Ogasawara Y.
Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells. Toxicol Appl Pharmacol. 305, 161-168 (2016)

5. Yokoya M, Toyoshima M, Suzuki T, Le V. H, Williams R. M and Saito N
Stereoselective Tota Synthesis of (-)-Renieramycin T. J. Org. Chem. 81, 4039-4047 (2016)

6. Toyoshima R, Mori N, Suzuki T, Lowtangkitcharoen W, Suwanborirux K, Saito N.
Chemisty of Ecteinascidins. Part 5. An Additional Proof of Cytotoxicity Evaluation of Ecteinascidin 770 Derivatives. Chem. Pharm. Bull, 64, 966-969 (2016)

2015年

1. Ogasawara Y, Ishida Y, Takikawa M, Funaki Y, Suzuki T, Koike S.
A simple high performance liquid chromatography method for quantitatively determining the reduced form of peroxiredoxin 2 and the mass spectrometric analysis of its oxidative status. J Chromatogr B Analyt Technol Biomed Life Sci. 997, 136-141 (2015)

2. Koike S, Shibuya N, Kimura H, Ishii K, Ogasawara Y.
Polysulfide promotes neuroblastoma cell differentiation by accelerating calcium influx. Biochem Biophys Res Commun. 459, 488-492 (2015)

3. Kimura Y, Toyofuku Y, Koike S, Shibuya N, Nagahara N, Lefer D, Ogasawara Y, Kimura H.
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. Sci Rep. 5, 14774 (2015)

4. Koike S, Kayama T, Arai M, Horiuchi Y, Kobori A, Miyashita M, Itokawa M, Ogasawara Y.
Characterization of modified proteins in plasma from a subtype of schizophrenia based on carbonyl stress: Protein carbonyl is a possible biomarker of psychiatric disorders. Biochem Biophys Res Commun. 467, 361-366 (2015)

5. Suzuki T, Ishibashi K, Yumoto A, Nishio K, Ogasawara Y.
A possible utilization of arsenic trioxide against cisplatin-resistant non-small cell lung cancer. Oncology letters 10, 805-809 (2015)

2014年

1. Ogasawara Y, Takeda Y, Takayama H, Nishimoto S, Ichikawa K, Ueki M, Suzuki T, Ishii K
Significance of the rapid increase in GSH levels in the protective response to cadmium exposure through phosphorylated Nrf2 signaling in Jurkat T-cells. Free Radic. Biol. Med. 69, 58-66 (2014)

2. Nagasawa I, Kaneko A, Suzuki T, Nishio K, Kinoshita K, Shiro M, Koyama K.
Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex. Journal of natural products 77, 963-968 (2014)

3. Ogasawara Y, Imase M, Oda H, Wakabayashi H, Ishii K.
Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage. Int. J. Mol. Sci. 15, 1003 (2014)

4. Ishida YI, Takikawa M, Suzuki T, Nagahama M, Ogasawara Y.
Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells. FEBS Open Bio. 4, 848 (2014)

2013年

1. Shibuya N, Koike S, Tanaka M, Ishigami-Yuasa M, Kimura Y, Ogasawara Y, Fukui K, Nagahara N, Kimura H.
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nature Commun. 4, 1366 (2013)

2. Ogasawara Y, Hirokawa T, Matsushima, Koike S, Shibuya N, Tanabe S, Ishii K.
A novel method for the analysis of 3-mercaptopyruvate using high-performance liquid chromatography with fluorescence detection. J. Chromatgr.,Bioanalyte B, 931, 56-60 (2013)

3. Koike S, Ogasawara Y, Shibuya N, Kimura H, Ishii K.
Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett. 587, 3548-3555 (2013)

4. Mikami Y, Shibuya N, Ogasawara Y, Kimura H.
Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca2+ concentrations. Biochem. Biophys. Res. Commun. 431 131-135 (2013)

5. Pouliot L. M, Shen D. W, Suzuki T, Hall M. D, Gottesman, M. M.
Contributions of microRNA dysregulation to cisplatin resistance in adenocarcinoma cells. Experimental cell research 319, 566-574 (2013)

2012年

1. Ogasawara Y, Ohminato T, Nakamura Y, Ishii K.
Structural and functional analysis of native peroxiredoxin 2 in human red blood cells. Int. J. Biochem. Cell Biol. 44,1072-1077 (2012)

2. Uemura M, Suzuki T, Nishio K, Chikum M, Komeda S.
An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles. Metallomics : integrated biometal science 4, 686-692 (2012)

総 説

1. 酸化ストレスマーカーの予防医学における実用性：小笠原裕樹、ぶんせき、18-23 (2008)
2. 生体内でシステインから産生される硫化水素と結合型イオウの生理的な役割: 小池伸、小笠原裕樹、硫酸と工業, 69, 167-178 (2016)
3. Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals. Koike S, Ogasawara Y. Molecules, 21, 1753 (2016)