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研究業績
横屋 正志
Masashi Yokoya
原著論文
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35. Chemistry of Renieramycins Part 18. Synthesis of Renieramycin M and So-called Fennebricin A from (+/-)-Jorunnamycin A
Masashi Yokoya, Kento Monden, Mitsuhiro Sato, Natchanun Sirimangkalakitti, Naoki Saito*
Heterocycles, 2020, 101 (2), 548-558.
DOI: 10.3987/com-19-s(f)45. -
34. Structure-Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells
Korrakod Petsri, Masashi Yokoya, Sucharat Tungsukruthai, Thanyada Rungrotmongkol, Bodee Nutho, Chanida Vinayanuwattikun, Naoki Saito, Matsubara Takehiro, Ryo Sato, Pithi Chanvorachote*
Cancers (Basel), 2020, 12 (4), 875.
DOI: 10.3390/cancers12040875. -
33. Preparation of Tricyclic Analog as CDE Ring Model of Renieramycin Marine Natural Product by Novel Photo-Induced Transformation of 6-Methoxy-1,2,3,4-Tetrahydroisoquinoline-5,8-dione
Masashi Yokoya, Shohei Takahashi, Naoki Saito*
Heterocycles, 2019, 99 (2), 1276-1303.
DOI: 10.3987/com-18-s(f)100. -
32. Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products
Takehiro Matsubara, Masashi Yokoya,* Natchanun Sirimangkalakitti, Naoki Saito*
Marine Drugs, 2019, 17 (1), 3.
DOI: 10.3390/md17010003. -
31. Stereoselective Total Synthesis of (-)-Renieramycin T
Masashi Yokoya,* Ryoko Toyoshima, Toshihiro Suzuki, Vy H. Le, Robert M. Williams,* Naoki Saito
Journal of Organic Chemistry, 2016, 81 (10), 4039-4047.
DOI: 10.1021/acs.joc.6b00327. -
30. Practical Synthesis of Tricyclic Lactam Model of Antitumor Renieramycin-Saframycin Natural Product
Masashi Yokoya, Akiya Fujino, Ayako Yaguchi, Miku Yamazaki, Naoki Saito*
Heterocycles, 2016, 93, 802-815.
DOI: 10.3987/COM-15-S(T)53. -
29. Synthesis and Absolute Configuration of Acanthodendrilline, a New Cytotoxic Bromotyrosine Alkaloid from the Thai Marine Sponge Acanthodendrilla sp
Nachanun Sirimangkalakitti, Masashi Yokoya, Supakarn Chamni, Pithi Chanvorachote, Anuchit Plubrukrn, Naoki Saito,* Khanit Suwanborirux*
Chemical & Pharmaceutical Bulletin, 2016, 64 (3), 258-262.
DOI: 10.1248/cpb.c15-00901. -
28. Chemistry of Antitumor Renieramycin Marine Natural Products
Masashi Yokoya, Naoki Saito*
Journal of Synthetic Organic Chemistry, Japan, 2015, 73, 723-736.
DOI: 10.5059/yukigoseikyokaishi.73.723. -
27. Chemistry of Renieramycins. Part 14: Total Synthesis of Renieramycin I and Practical Synthesis of Cribrostatin 4 (Renieramycin H)
Masashi Yokoya, Keiichiro Kobayashi, Mitsuhiro Sato, Naoki Saito*
Marine Drugs, 2015, 13, 4915-4933.
DOI: 10.3390/md13084915. -
26. Synthetic Studies on Saframycin Anibiotics: An Improved Synthesis of Tricyclic Lactam Intermediate and Construction of the Core Ring System of Saframycin A
Shinya Kimura, Shintaro Kawai, Masayuki Azuma, Yoshifumi Umehara, Yu-ichi Koizumi, Masashi Yokoya, Naoki Saito*
Heterocycles, 2015, 90, 327-343.
DOI: 10.3987/COM-14-S(K)24. -
25. Isolation, Structure Characterization, and Synthesis of Stabilized 1,2,3,4-Tetrahydroisoquinoline Marine Natural Product from Potassium Cyanide Pretreated Thai Tunicate, Ecteinascidia thurstoni
Shinya Kimura, Waree Pangkruang, Masashi Yokoya, Amane Honda, Ploenthip Puthongking, Khanit Suwanborirux,* Naoki Saito*
Heterocycles, 2014, 88, 363-375.
DOI: 10.3987/COM-13-S(S)32. -
24. Preparation of renieramycin left-half model compounds
Keiyo Nakai, Keiji Kubo, Masashi Yokoya, Naoki Saito*
Tetrahedron, 2014, 70, 6529-6545.
DOI: 10.1016/j.tet.2014.07.012. -
23. Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate
Keiyo Nakai, Masashi Yokoya, Naoki Saito*
Chemical & Pharmaceutical Bulletin, 2013, 61 (8), 853-869.
DOI: 10.1248/cpb.c13-00361. -
22. Chemistry of renieramycins. Part 12: An improved total synthesis of (±)-renieramycin G
Masashi Yokoya, Kimiko Shinada-Fujino, Saiko Yoshida, Masahiro Mimura, Hiroki Takada, Naoki Saito*
Tetrahedron, 2012, 68, 4166-4181.
DOI: 10.1016/j.tet.2012.03.105. -
21. Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W–Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide
Mari Tatsukawa, Louvy Lynn C Punzalan, Hilbert D.S. Magpantay, Irene M. Villaseñor, Gisela P. Concepcion, Khanit Suwanborirux, Masashi Yokoya, Naoki Saito*
Tetrahedron, 2012, 68, 7422-7428.
DOI: 10.1016/j.tet.2012.06.067. -
20. Chemistry of renieramycins. Part 9: Stereocontrolled total synthesis of (±)-renieramycin G
Masashi Yokoya, Kimiko Shinada-Fujino, Naoki Saito*
Tetrahedron Letters, 2011, 52, 2446-2449.
DOI: 10.1016/j.tetlet.2011.02.055. -
19. Chemistry of renieramycins. Part 11: Total synthesis of (±)-cribrostatin 4
Masashi Yokoya, Hiroshi Ito, Naoki Saito*
Tetrahedron, 2011, 67 (47), 9185-9192.
DOI: 10.1016/j.tet.2011.09.076. -
18. Synthesis of Renieramycins: Construction of the Core Ring System of Cribrostatin 4 through Modified Pictet–Spengler Cyclization of 3,6-Bisarylpiperazine-2,5-dione with Diethoxyethyl Benzoate
Masashi Yokoya, Hiroshi Ito, Naoki Saito*
Chemical & Pharmaceutical Bulletin, 2011, 59, 787-792.
DOI: 10.1248/cpb.59.787. -
17. Microarray-based transcriptional profiling of renieramycin M and jorunnamycin C, isolated from Thai marine organisms
Kornvika Charupant, Khanit Suwanborirux,* Naomi Daikuhara, Masashi Yokoya, Rie Ushijima-Sugano, Takatoshi Kawai, Takashi Owa,* Naoki Saito*
Marine Drugs, 2009, 7 (4), 483-494.
DOI: 10.3390/md7040483. -
16. Synthesis of Tetrahydroisoquinoline Antitumor Natural Products: Construction of Tricyclic Lactams Through Pictet-Spengler-Type Cyclization of N-Methyl-3-arylmethylpiperazine-2,5-dione with Ethyl Diethoxyacetate
Masashi Yokoya, Osamu Kawachi, Naoki Saito*
Heterocycles, 2008, 76, 1497-1509.
DOI: 10.3987/COM-08-S(N)114. -
15. Total Synthesis of ent -Dihydrocorynantheol by Using a Proline-Catalyzed Asymmetric Addition Reaction
Takashi Itoh,* Masashi Yokoya, Keiko Miyauchi, Kazuhiro Nagata, Akio Ohsawa
Organic Letters, 2006, 8, 1533-1535.
DOI: 10.1021/ol0530575. -
14. Total Synthesis of ent -Sedridine Using Proline-Catalyzed Asymmetric Addition as a Key Step
Takashi Itoh,* Kosuke Nishimura, Kazuhiro Nagata, Masashi Yokoya
Synlett, 2006, 2006, 2207-2210.
DOI: 10.1055/s-2006-948203. -
13. Enantioselective Synthesis of ent-Sedridine and (+)-Coniine via Proline-Catalyzed Mannich Reaction
Kazuhiro Nagata, Kosuke Nishimura, Masashi Yokoya, Takashi Itoh*
Heterocycles, 2006, 70, 335.
DOI: 10.3987/COM-06-S(W)29. -
12. Two New Nor-triterpene Glycosides from Peruvian “Uña de Gato”(Uncaria tomentosa)
Mariko Kitajima, Ken-ichiro Hashimoto, Masashi Yokoya, Hiromitsu Takayama, Manuel Sandoval, Norio Aimi*
Journal of Natural Products, 2003, 66, 320-323.
DOI: 10.1021/np0203741. -
11. Proline-Catalyzed Asymmetric Addition Reaction of 9-Tosyl-3,4-dihydro-β-carboline with Ketones
Takashi Itoh, Masashi Yokoya, Keiko Miyauchi, Kazuhiro Nagata, Akio Ohsawa*
Organic Letters, 2003, 5, 4301-4304.
DOI: 10.1021/ol030103x. -
10. The Synthesis of Isoquinoline Alkaloid and Its Related Compounds Using Alanine Derivatives as Chiral Auxiliaries
Takashi Itoh, Kazuhiro Nagata, Masashi Yokoya, Michiko Miyazaki, Keiko Kameoka, Shigeru Nakamura, Akio Ohsawa*
Chemical & Pharmaceutical Bulletin, 2003, 51, 951-955.
DOI: 10.1248/cpb.51.951. -
9. A general method for the asymmetric synthesis of both enantiomers of 1-substituted 1,2,3,4-tetrahydro-β-carbolines employing pyroglutamic acid derivatives as chiral auxiliaries
Takashi Itoh, Michiko Miyazaki, Sachiko Ikeda, Kazuhiro Nagata, Masashi Yokoya, Yuji Matsuya, Yasuko Enomoto, Akio Ohsawa*
Tetrahedron, 2003, 59, 3527-3536.
DOI: 10.1016/S0040-4020(03)00420-4. -
8. Synthesis and CD Measurement of Chiral 1-Ethyl-3-carboxy-1,2,3,4-tetrahydro-b- carbolines: C1 Configuration and Second Sphere Chirality
Masashi Yokoya, Kyohei Masubuchi, Mariko Kitajima, Hiromitsu Takayama, Norio Aimi*
Heterocycles, 2003, 59, 521.
DOI: 10.3987/COM-02-S87. -
7. Concise Syntheses of Harmicine and a Pyrrolidinoisoquinoline Derivative Using Chiral 1-Allyl Adducts of β-Carboline and Isoquinoline as Starting Materials
Akio Ohsawa, Takashi Itoh, Michiko Miyazaki, Kazuhiro Nagata, Masashi Yokoya, Shigeru Nakamura*
Heterocycles, 2002, 58, 115.
DOI: 10.3987/COM-02-S(M)49. -
6. Synthesis and absolute configuration of a new 3,4-dihydro-beta-carboline-type alkaloid, 3,4-dehydro-5(S)-5-carboxystrictosidine, isolated from Peruvian Uña de Gato (Uncaria tomentosa).
Mariko Kitajima, Masashi Yokoya, Hiromitsu Takayama, Norio Aimi*
Chemical & Pharmaceutical Bulletin, 2002, 50, 1376-1378.
DOI: 10.1248/cpb.50.1376. -
5. A New Entry to Asymmetric Synthesis of 1-Substituted 1,2,3,4-Tetrahydro-β-carbolines Employing a Pyroglutamic Acid Derivative as a Chiral Auxiliary
Takashi Itoh, Kazuhiro Nagata, Masashi Yokoya, Michiko Miyazaki, Sachiko Ikeda, Yuji Matsuya, Yasuko Enomoto, Akio Ohsawa*
Synlett, 2002, 2002, 1005-1007.
DOI: 10.1055/s-2002-31931. -
4. Collision-induced dissociation actualized the H+-promoted reaction as observed in vitro; harman formation from beta-carboline-type monoterpenoid glucoindole alkaloids.
Norio Aimi,* Mariko Kitajima, Masashi Yokoya, Hiromitsu Takayama, Shigeru Sakamoto, Kentaro Yamaguchi
Chemical & Pharmaceutical Bulletin, 2002, 50, 1528-1529.
DOI: 10.1248/cpb.50.1528. -
3. Co-occurrence of Harman and β-Carboline-type Monoterpenoid Glucoindole Alkaloids in Una de Gato (Uncaria tomentosa)
Mariko Kitajima, Masashi Yokoya, Hiromitsu Takayama, Norio Almi*
Tetrahedron Letters, 1999, 40 (8), 1555–1558.
Natural Medicines, 2001, 55, 308-310. -
2. Two New 19-Hydroxyursolic Acid-type Triterpenes from Peruvian ‘Uña de Gato’ (Uncaria tomentosa)
Mariko Kitajima, Ken-ichiro Hashimoto, Masashi Yokoya, Hiromitsu Takayama, Norio Aimi*
Tetrahedron, 2000, 56, 547-552.
DOI: 10.1016/S0040-4020(99)01048-0. -
1. A new gluco indole alkaloid, 3, 4-dehydro-5-carboxystrictosidine, from Peruvian Una de Gato (Uncaria tomentosa)
Mariko Kitajima, Ken-ichiro Hashimoto, Masashi Yokoya, Hiromitsu Takayama, Norio Aimi,* Shin-ichiro Sakai
Chemical & Pharmaceutical Bulletin, 2000, 48 (10), 1410-1412.
DOI: 10.1248/cpb.48.1410.
