HOME齋藤 望（Nozomi Saito）
略歴
昭和47年（1972）11月 北海道旭川市生まれ
学歴
| 平成3年（1991）3月 | 北海道旭川東高等学校 卒業 |
| 平成3年（1991）4月 | 北海道大学教養部理II系 入学 |
| 平成5年（1993）4月 | 北海道大学薬学部製薬化学科 進学 |
| 平成7年（1995）3月 | 北海道大学薬学部製薬化学科 卒業 (生体分子構造学講座・森美和子教授) |
| 平成9年（1997）3月 | 北海道大学大学院薬学研究科修士課程 修了(精密合成化学講座・森美和子教授) |
| 平成12年（2000）3月 | 北海道大学大学院薬学研究科博士課程 修了 博士(薬学)取得 (精密合成化学分野・森美和子教授) |
| 論文題目「ニッケル触媒による不斉環化反応の開発及びビスメタル化反応への展開」 |
職歴
| 平成12年（2000）4月 | 日本学術振興会特別研究員(PD) (森美和子教授) |
| ～平成14年（2002）3月 | |
| 平成12年(2000) 9月 | 米国カリフォルニア大学サンタバーバラ校化学科博士研究員 (B. H. Lipshutz教授) |
| ～平成13年（2001）8月 | |
| 平成14年（2002）4月 | 帝京大学薬学部 助手（薬化学教室、高山浩明教授（～2003）、橘高敦史教授（2003～)） |
| 平成17年（2005）4月 | 帝京大学薬学部 講師（橘高敦史教授） |
| 平成18年（2006）10月 | 北海道大学大学院薬学研究院 助教授（創薬科学部門創薬化学分野精密合成化学研究室、佐藤美洋教授） |
| 平成19年（2007）4月 | 北海道大学大学院薬学研究院 准教授 |
| 平成27年（2015）4月 | 明治薬科大学薬品製造化学研究室 教授 |
| 現在に至る |
所属学会
日本薬学会、日本化学会、有機合成化学協会、近畿化学協会、アメリカ化学会
受賞歴
平成18年（2006）10月 日本薬学会関東支部奨励賞「強力なビタミンD受容体アンタゴニストの創製に関する研究」
平成29年（2017）7月 明治薬科大学平成28年度学部授業ベストティーチャー
平成29年（2017）10月 明治薬科大学平成28年度大学院講義ベストティーチャー
平成30年（2018）7月 明治薬科大学平成29年度学部授業ベストティーチャー
令和元年（2019）7月 明治薬科大学平成30年度学部授業ベストティーチャー
令和2年（2020）11月 明治薬科大学令和元年度学部授業ベストティーチャー
令和2年（2020）11月 明治薬科大学令和元年度大学院講義ベストティーチャー
研究業績
原著論文
| 65. | Masanori Tayu, Ryuta Watanabe, Satoshi Isogi, Nozomi Saito |
| "A Catalytic Construction of Indoles via Formation of Ruthenium Vinylidene Species from N‐Arylynamides" | |
| Adv. Synth. Catal. 2021, 363, 1147-1151.[DOI] | |
| 64. | Takahisa Taniguchi, Nozomi Saito, Ryohei Doi, Arato Kimoto, Naoyuki Hoshiya, Katsumasa Fujiki, Satoshi Shuto, |
| Hiromichi Fujioka, Mitsuhiro Arisawa, Yoshihiro Sato | |
| "Nickel Nanoparticle-Catalyzed Carboxylation of Unsaturated Hydrocarbon with CO2 Using Sulfur-Modified Au-Supported Nickel Materia" | |
| Chem. Lett. 2019, 48, 1406-1409. [DOI] | |
| 63. | Koichi Katagiri, Haruka Kodera, Masanori Tayu, Nozomi Saito |
| "Facile Construction of an α-(1-Cyclopentenyl)ketone Core by Ruthenium-Catalyzed Hydrative Cyclization of 1,6-Allenyne: Total Synthesis of (+)-Myomontanone" | |
| Chem. Lett. 2019, 48, 768-770. [DOI] | |
| 62. | Nozomi Saito, Momoko Koyama, Yoshihiro Sato |
| "Ruthenium-Catalyzed [2 + 2] Cyclization of 1,7-Allenynes in Ionic Liquid and Catalyst Recycling" | |
| Heterocycles 2018, 97, 696-701. [DOI] | |
| 61. | Hiroki Mano, Shinichi Ikushiro, Nozomi Saito, Atsushi Kittaka, Toshiyuki Sakaki |
| "Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique" | |
| J. Steroid Biochem. Mol. Biol. 2018, 178, 55-59. [DOI] | |
| 60. | Masanori Tayu, Yi Hui, Shiori Takeda, Kazuhiro Higuchi, Nozomi Saito, Tomomi Kawasaki |
| "Total Synthesis of (+)-Gliocladin C Based on One-Pot Construction of a 3a-(3-Indolyl)pyrroloindoline Skeleton by Sulfonium-Mediated Cross-Coupling of Tryptophan and Indole" | |
| Org. Lett. 2017, 19 (24), 6582–6585. [DOI] | |
| 59. | Masanori Tayu, Kazuya Nomura, Koki Kawachi, Kazuhiro Higuchi, Nozomi Saito, Tomomi Kawasaki |
| "Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt" | |
| Chem. Eur. J. 2017, 23 (45), 10925-10930. [DOI] | |
| 58. | Toshiki Akiyama, Takahisa Taniguchi, Nozomi Saito, Ryohei Doi, Tetsuo Honma, Yusuke Tamenori, Yuuta Ohki, Naoyuki Takahashi, |
| Hiromichi Fujioka, Yoshihiro Sato, Mitsuhiro Arisawa | |
| "Ligand-Free Suzuki–Miyaura Coupling Using Ruthenium(0) Nanoparticles and a Continuously Irradiating Microwave System" | |
| Green Chem. 2017, 19 (14), 3357-3369. [DOI] | |
| 57. | Ryohei Doi, Iman Abdullah, Takahisa Taniguchi, Nozomi Saito, Yoshihiro Sato |
| "Nickel-Catalyzed Hydrocarboxylation of Ynamides with CO2 and H2O: An Observation of Unexpected Regioselectivity" | |
| Chem. Commun. 2017, 53 (55), 7720-7723 [DOI] | |
| 56. | Hiroki Mano, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Nozomi Saito, Daisuke Sawada, Shinobu Honzawa, Masashi Takano, |
| Atsushi Kittaka, Toshiyuki Sakaki | |
| “Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor” | |
| J. Steroid Biochem. Mol. Biol., 2017, 167, 61-67. [DOI] | |
| 55. | Nozomi Saito, Iman Abdullah, Kayoko Hayashi, Katsuyuki Hamada, Momoko Koyama, Yoshihiro Sato |
| "Enantioselective synthesis of β-amino acid derivatives via nickel-promoted regioselective carboxylation of ynamides | |
| and rhodium-catalyzed asymmetric hydrogenation" | |
| Org. Biomol. Chem. 2016, 14 (24), 10080-10089. [DOI] | |
| 54. | Naoyuki Hoshiya, Katsumasa Fujiki, Takahisa Taniguchi, Tetsuo Honma, Yusuke Tamenori, Mincen Xiao, Nozomi Saito, |
| Mami Yokoyama, Akira Ishii, Hiromichi Fujioka, Satoshi Shuto, Yoshihiro Sato, Mitsuhiro Arisawa | |
| "Self-Assembled Multilayer-Stabilized Nickel Nanoparticle Catalyst for Ligand-Free Cross-Coupling Reactions: in situ Metal Nanoparticle and Nanospace Simultaneous Organization" | |
| Adv. Synth. Catal. 2016, 358 (15), 2449-2459. [DOI] | |
| 53. | Hiroki Mano, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Nozomi Saito, Masashi Takano, Atsushi Kittaka, Toshiyuki Sakaki |
| "Development of novel bioluminescent sensor to detect and discriminate between vitamin D receptor agonists and antagonists in living cells" | |
| Bioconjugate Chem. 2015, 26 (10), 2036-2045. [DOI] | |
| 52. | Nozomi Saito, Zhongdong Sun, Yoshihiro Sato |
| "Nickel-Promoted Highly Regioselective Carboxylation of Aryl Ynol Ether and Its Application to the Synthesis of Chiral β-Aryloxypropionic Acid Derivatives" | |
| Chem. Asian J. 2015, 10 (5), 1170-1176. [DOI] | |
| Selected as a "Bcakside Cover" of Chem. Asian J. 5/2015 !! | |
| 51. | Nozomi Saito, Takahisa Taniguchi, Naoyuki Hoshiya, Satoshi Shuto, Mitsuhiro Arisawa, Yoshihiro Sato |
| "Double Carbonylation of Aryl Iodides with Amines under an Atmospheric Pressure of Carbon Monoxide Using Sulfur-Modified Au-Supported Palladium" | |
| Green Chem. 2015, 17 (4), 2358-2361. [DOI] | |
| 50. | Nozomi Saito, Yasuyuki Sugimura, Yoshihiro Sato |
| "Nickel(0)-Promoted Carboxylation of Allenamides with Carbon Dioxide via a Nickelalactone Intermediate" | |
| Synlett 2014, 25 (5), 736-740. [DOI] | |
| 49. | Nozomi Saito, Ken-ichi Nakamura, Yoshihiro Sato |
| "1,3-Dipolar Cycloaddition of Pyridynes and Azides: Concise Synthesis of Triazolopyridines" | |
| Heterocycles 2014, 88 (2), 929-937. [DOI] | |
| 48. | Nozomi Saito, Keichi Saito, Hiroyasu Sato, Yoshihiro Sato |
| "Regio- and Stereoselective Synthesis of Tri- and Tetrasubstituted Enamides via Palladium-Catalyzed Silaboration of Ynamides" | |
| Adv. Synth. Catal. 2013, 355 (5), 853-856. [DOI] | |
| 47. | Nozomi Saito, Ken-ichi Nakamura, Sayako Shibano, Soichiro Ide, Masabumi Minami, Yoshihiro Sato |
| "Addition of Cyclic Ureas and 1-Methyl-2-oxazolidone to Pyridynes: A New Approach to Pyridodiazepines, Pyridodiazocines, and Pyridooxazepines" | |
| Org. Lett. 2013, 15 (2), 386-389. [DOI] | |
| 46. | Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Masashi Takano, Nozomi Saito, Atsushi Kittaka, Tai C. Chen, Miho Ohta, |
| Toshiyuki Sakaki | |
| "Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D3 analogs" | |
| J. Steroid Biochem. Mol. Biol. 2013, 133 (1) 84-92 [DOI] | |
| 45. | Nozomi Saito, Taisuke Ichimaru, Yoshihiro Sato |
| "Ruthenium-Catalyzed Intramolecular [2 + 2 + 2] Cyclization of Allene-Yne-Enes: Construction of Fused-Tricyclic Skeleton" | |
| Chem. Asian J. 2012, 7 (7), 1521-1523. [DOI] | |
| 44. | Nozomi Saito, Taisuke Ichimaru, Yoshihiro Sato |
| "Total Synthesis of (-)-Herbindoles A, B, and C via Transition Metal-Catalyzed Intramolecular [2+2+2] Cyclization between Ynamide and Diynes" | |
| Org. Lett. 2012, 14 (7), 1914-1917. [DOI] | |
| 43. | Nozomi Saito, Yuh Kohyama, Yuki Tanaka, Yoshihiro Sato |
| "Synthesis of 1,2-Bisalkylidenecyclopentanes from 1,6-Allenynes via Stereoselective Addition of Nucleophiles to Ruthenacyclopentenes" | |
| Chem. Commun. 2012, 48 (31), 3754-3756. [DOI] | |
| 42. | Nozomi Saito, Ayami Kobayashi, Yoshihiro Sato |
| "Nickel-Catalyzed Enantio- and Diastereoselective Three-Component Coupling of 1,3-Diene, Aldehyde, and Silylborane Leading to an α-Chiral Allylsilane" | |
| Angew. Chem. Int. Ed. 2012, 51 (5), 1228-1231. [DOI] | |
| 41. | Kanako Shindo, Go Kumagai, Masashi Takano, Daisuke Sawada, Nozomi Saito, Hiroshi Saito, Shinji Kakuda, Ken-ichiro Takagi, Eiji Ochiai, |
| Kyohei Horie, Midori Takimoto-Kamimura, Seiichi Ishizuka, Kazuya Takenouchi, Atsushi Kittaka | |
| "New C15-Substituted Active Vitamin D3" | |
| Org. Lett. 2011, 13 (11), 2852-2855. [DOI] | |
| 40. | Nozomi Saito, Keiichi Saito, Yoshihiro Sato |
| "Regio- and Stereoselective Synthesis of 2-Amino-1,3-Diene Derivatives by Ruthenium-Catalyzed Coupling of Ynamides and Ethylene" | |
| Org. Lett. 2011, 13 (10), 2718-2721. [DOI] | |
| 39. | Nozomi Saito, Tomoyuki Katayama, Yoshihiro Sato |
| "Asymmetric Synthesis of γ-Siloxyenamides via Chiral Auxiliary-Mediated Diastereoselective Coupling of Ynamides, Aldehydes and Silane by Nickel Catalyst" | |
| Heterocycles 2011, 82 (2), 1181-1187. [DOI] | |
| 38. | Nozomi Saito, Yasuyuki Sugimura, Yoshihiro Sato |
| "A Facile Construction of Bi- or Tricyclic Skeletons by Nickel-Catalyzed Stereoselective Cyclization of Alkynylcycloalkanone" | |
| Org. Lett. 2010, 12 (15), 3494-3497. [DOI] | |
| 37. | Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Hiroshi Saito, Ken-ichiro Takagi, Eiji Ochiai, |
| Seiichi Ishizuka, Kazuya Takenouchi, Atsushi Kittaka | |
| "Synthesis of 2α- and 2β-substituted-14-epi-previtamin D3 and their genomic activity" | |
| Tetrahedron 2010, 66 (29), 5407-5423. [DOI] | |
| 36. | Nozomi Saito, Yuki Tanaka, Yoshihiro Sato |
| "Ruthenium-Catalyzed [2+2] Cycloaddition of Allenynes Leading to a Bicyclo[4.2.0]octa-1(8),5-diene Skeleton" | |
| Org. Lett. 2009, 11 (18), 4124-4126. [DOI] | |
| 35. | Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Masashi Takano, Hiroshi Saito, Ken-ichiro Takagi, Eiji Ochiai, |
| Seiichi Ishizuka, Kazuya Takenouchi, Atsushi Kittaka | |
| "Synthesis of 2α-substituted-14-epi-previtamin D3 and its genomic activity" | |
| Bioorg. Med. Chem. Lett. 2009, 19 (18), 5397-5400. [DOI] | |
| 34. | Nozomi Saito, Kengo Shiotani, Atsushi Kinbara, Yoshihiro Sato |
| "Nickel-Catalyzed [2+2+2] Cycloaddition of Aryne and Unactivated Alkene: Synthesis of 9,10-Dihydrophenanthrene Derivatives" | |
| Chem. Commun. 2009, (28), 4284-4286. [DOI] | |
| 33. | Nozomi Saito, Yoshitomo Suhara, Daisuke Abe, Tatsuya Kusudo, Miho Ohta, Kaori Yasuda, Toshiyuki Sakaki, Shinobu Honzawa, |
| Toshie Fujishima, Atsushi Kittaka | |
| "Synthesis of 2α-Propoxy-1α,25-dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1" | |
| Bioorg. Med. Chem. 2009, 17 (13), 4296-4301. [DOI] | |
| 32. | Nozomi Saito, Tetsuro Yamazaki, Yoshihiro Sato |
| "Diastereoselective Coupling of 1,3-Diene, Ketone, and Organometallic Reagents by Nickel Catalyst: Stereoselective Construction of Tetrasubstituted Carbon Centers" | |
| Chem. Lett. 2009, 38 (6), 594-595. [DOI] | |
| 31. | Nozomi Saito, Yuki Tanaka, Yoshihiro Sato |
| "Ruthenium-Catalyzed Cyclodimerization of Allenynes" | |
| Organometallics 2009, 28 (3), 669-671. [DOI] | |
| 30. | Miwako Mori, Daisuke Tanaka, Nozomi Saito, Yoshihiro Sato |
| "Ruthenium-Catalyzed Alkenylative Cyclization via Insertion of Alkene into Ruthenacyclopentene" | |
| Organometallics 2008, 27 (23), 6313-6320. [DOI] | |
| 29. | Nozomi Saito, Tomoyuki Katayama, Yoshihiro Sato |
| "Nickel-Catalyzed Highly Regioselective Three-Component Coupling of Ynamides, Aldehydes, and Silane: A New Access to Functionalized Enamides" | |
| Org. Lett. 2008, 10 (17), 3829-3832. [DOI] | |
| 28. | Nozomi Saito, Tetsuro Yamazaki, Yoshihiro Sato |
| "Nickel(0)-Catalyzed Diastereoselective Three-Component Coupling of 1,3-Dienes, Aldehydes and Organometallic Reagents: Influence of Organometallic Reagents on Diastereoselectivity" | |
| Tetrahedron Lett. 2008, 49 (34), 5073-5076. [DOI] | |
| 27. | Wataru Hakamata, Yukiko Sato, Haruhiro Okuda, Shinobu Honzawa, Nozomi Saito, Seishi Kishimoto, Atsushi Yamamoto, |
| Takayuki Sugiura, Atsushi Kittaka, Masaaki Kurihara | |
| "(2S,2'R)-Analogue of LG190178 Is a Major Active Isomer" | |
| Bioorg. Med. Chem. Lett. 2008, 18 (1), 120-123. [DOI] | |
| 26. | Yoshihiro Sato, Yu Hinata, Reiko Seki, Yoshihiro Oonishi, Nozomi Saito |
| "Nickel-Catalyzed Enantio- and Diastereoselective Three-Component Coupling of 1,3-Dienes, Aldehydes, and Silanes Using Chiral N-Heterocyclic Carbenes as Ligands" | |
| Org. Lett. 2007, 9 (26), 5597-5599. [DOI] | |
| 25. | Nozomi Saito, Miwako Mori, Yoshihiro Sato |
| "Ni(0)-Catalyzed Disilylative and Silastannylative Cyclizations of 1,3-Diene and Tethered Aldehyde" | |
| J. Organomet. Chem. 2007, 692 (1-3), 460-471. [DOI] | |
| 24. | Nozomi Saito, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Jun-ichi Namekawa, |
| Seiichi Ishizuka, Atsushi Kittaka | |
| "Further Synthetic and Biological Studies on Vitamin D Hormone Antagonists Based on C24-Alkylation and C2α-Functionalization of 25-Dehydro-1α-hydroxyvitamin D3-26,23-lactones" | |
| J. Med. Chem. 2006, 49 (24), 7063-7075. [DOI] | |
| 23. | Miwako Mori, Hideaki Wakamatsu, Nozomi Saito, Yukako Sato, Rie Narita, Yoshihiro Sato, Reiko Fujita |
| "Synthesis of Cyclic Dienamide Using Ruthenium-Catalyzed Ring-Closing Metathesis of Ene-Ynamide" | |
| Tetrahedron 2006, 62 (16), 3872-3881. [DOI] | |
| 22. | Nozomi Saito, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, |
| Hiroaki Takayama, Atsushi Kittaka | |
| "Synthesis and 2α-Modification of 24-Phenylvitamin D3 Lactones: Effects on VDR Antagonistic Activity" | |
| Heterocycles 2006, 67 (1), 311-336. [DOI] | |
| 21. | Shinobu Honzawa, Koshiro Hirasaka, Yasuhiro Yamamoto, Sara Peleg, Toshie Fujishima, Masaaki Kurihara, Nozomi Saito, Seishi Kishimoto, |
| Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka | |
| "Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D3 analogues possessing aromatic ring on 2α-position" | |
| Tetrahedron 2005, 61 (47), 11253-11263. [DOI] | |
| 20. | Nozomi Saito, Manami Masuda, Hiroshi Saito, Kazuya Takenouchi, Seiichi Ishizuka, Jun-ichi Namekawa, |
| Midori Takimoto-Kamimura, Atsushi Kittaka | |
| "Synthesis of 24,24-Ethanovitamin D3 Lactones Using Ruthenium-Catalyzed Intermolecular Enyne Metathesis: Potent Vitamin D Receptor Antagonists" | |
| Synthesis 2005, (15), 2533-2543. [DOI] | |
| 19. | Daisuke Abe, Toshiyuki Sakaki, Tatsuya Kusudo, Atsushi Kittaka, Nozomi Saito, Yoshitomo Suhara, Toshie Fujishima, |
| Hiroaki Takayama, Hiromi Hamamoto, Masaki Kamakura, Miho Ohta, Kuniyo Inouye | |
| "Metabolism of 2α-propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1" | |
| Drug Metab. Dispos. 2005, 33 (6), 778-784. [DOI] | |
| 18. | Nozomi Saito, Yoshitomo Suhara, Masaaki Kurihara, Toshie Fujishima, Shinobu Honzawa, Hitoshi Takayanagi, |
| Toshiro Kozono, Masahiko Matsumoto, Masayuki Ohmori, Naoki Miyata, Hiroaki Takayama, Atsushi Kittaka | |
| "Design and Efficient Synthesis of 2-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity" | |
| J. Org. Chem. 2004, 69 (22), 7463-7471. [DOI] | |
| 17. | Nozomi Saito, Manami Masuda, Toshihiro Matsunaga, Hiroshi Saito, Miyuki Anzai, Kazuya Takenouchi, Daishiro Miura, |
| Seiichi Ishizuka, Midori Takimoto-Kamimura, Atsushi Kittaka | |
| "24,24-Dimethylvitamin D3-26,23-lactones and Their 2α-Functionalized Analogues as Highly Potent VDR Antagonists" | |
| Tetrahedron 2004, 60 (36), 7951-7961. [DOI] | |
| 16. | Yoshitomo Suhara, Keiichiro Ono, Akihiro Yoshida, Toshie Fujishima, Nozomi Saito, Shinobu Honzawa, Seishi Kishimoto, |
| Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka | |
| "Synthesis of Novel 1α,25-Dihydroxy-19-Norvitamin D3 with an Amide Conjugate" | |
| Heterocycles 2004, 62 (1), 423-436. [DOI] | |
| 15. | Nozomi Saito, Hiroshi Saito, Miyuki Anzai, Akihiro Yoshida, Toshie Fujishima, Kazuya Takenouchi, Daishiro Miura, Seiichi Ishizuka, |
| Hiroaki Takayama, Atsushi Kittaka | |
| "Dramatic Enhancement of Antagonistic Activity on Vitamin D Receptor: A Double Functionalization of 1α-Hydroxyvitamin D3-26,23-Lactones" | |
| Org. Lett. 2003, 5 (25), 4859-4862. [DOI] | |
| 14. | Nozomi Saito, Toshihiro Matsunaga, Toshie Fujishima, Miyuki Anzai, Hiroshi Saito, Kazuya Takenouchi, Daishiro Miura, |
| Seiichi Ishizuka, Hiroaki Takayama, Atsushi Kittaka | |
| "Remarkable Effect of 2α-Modification on the VDR Antagonistic Activity of 1α-Hydroxyvitamin D3-26,23-lactones" | |
| Org. Biomol. Chem. 2003, 1 (24), 4396-4402. [DOI] | |
| 13. | Shinobu Honzawa, Yoshitomo Suhara, Ken-ichi Nihei, Nozomi Saito, Seishi Kishimoto, Toshie Fujishima, Masaaki Kurihara, |
| Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka | |
| "Concise Synthesis and Biological Activities of 2α-Alkyl- and 2α-(ω-Hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D3" | |
| Bioorg. Med. Chem. Lett. 2003, 13 (20), 3503-3506. [DOI] | |
| 12. | Keiichiro Ono, Akihiro Yoshida, Nozomi Saito, Toshie Fujishima, Shinobu Honzawa, Yoshitomo Suhara, Seishi Kishimoto, |
| Takayuki Sugiura, Keizo Waku, Hiroaki Takayama, Atsushi Kittaka | |
| "Efficient Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells" | |
| J. Org. Chem. 2003, 68 (19), 7407-7415. [DOI] | |
| 11. | Akihiro Yoshida, Keiichiro Ono, Yoshitomo Suhara, Nozomi Saito, Hiroaki Takayama, Atsushi Kittaka |
| "Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2α- and 2β-Alkylated 1α,25-Dihydroxy-19-norvitamin D3 Analogues" | |
| Synlett 2003, (8), 1175-1179. [DOI] | |
| 10. | Miwako Mori, Nozomi Saito, Daisuke Tanaka, Masanori Takimoto, Yoshihiro Sato |
| "Novel Alkenylative Cyclization Using a Ruthenium Catalyst" | |
| J. Am. Chem. Soc. 2003, 125 (19), 5606-5607. [DOI] | |
| 9. | Yoshihiro Sato, Nozomi Saito, Miwako Mori |
| Asymmetric Cyclization of ω-Formyl-1,3-Dienes Catalyzed by Zerovalent Nickel Complex in the Presence of Silanes" | |
| J. Org. Chem. 2002, 67 (26), 9310-9317. [DOI] | |
| 8. | Yoshitomo Suhara, Atsushi Kittaka, Seishi Kishimoto, Martin J. Calverley, Toshie Fujishima, Nozomi Saito, Takayuki Sugiura, |
| Keizo Waku, Hiroaki Takayama | |
| "Synthesis and Testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differentiation Activity" | |
| Bioorg. Med. Chem. Lett. 2002, 12 (22), 3255-3258. [DOI] | |
| 7. | Gerhard Bringmann, Dirk Menche, Jörg Mühlbacher, Matthias Reichert, Nozomi Saito, Steven S. Pfeiffer, Bruce H. Lipshutz |
| "On the Verge of Axial Chirality: Atroposelective Synthesis of the AB-Biaryl Fragment of Vancomycin" | |
| Org. Lett. 2002, 4 (17), 2833-2836. [DOI] | |
| 6. | Nozomi Saito, Yukako Sato, Miwako Mori |
| "Synthesis of Cyclic Dienamide Using Ruthenium-Catalyzed Ring-Closing Metathesis of Ene-Ynamide" | |
| Org. Lett. 2002, 4 (5), 803-805. [DOI] | |
| 5. | Yoshihiro Sato, Rieko Sawaki, Nozomi Saito, Miwako Mori |
| "Nickel-Catalyzed Intermolecular Coupling of 1,3-Dienes and Aldehydes via Transmetalation of Nickelacycles with Diisobutylaluminum Acetylacetonate" | |
| J. Org. Chem. 2002, 67 (3), 656-662. [DOI] | |
| 4. | Yoshihiro Sato, Nozomi Saito, Miwako Mori |
| "Ni(0)-Catalyzed Bismetallative Cyclization of 1,3-Diene and a Tethered Aldehyde in the Presence of Bu3SnSiMe3" | |
| Chem. Lett. 2002, (1), 18-19. [DOI] | |
| 3. | Yoshihiro Sato, Nozomi Saito, Miwako Mori |
| "A Novel Asymmetric Cyclization of ω-Formyl-1,3-Dienes Catalyzed by Zerovalent Nickel Complex in the Presence of Silanes" | |
| J. Am. Chem. Soc. 2000, 122 (10), 2371-2372. [DOI] | |
| 2. | Yoshihiro Sato, Nozomi Saito, Miwako Mori |
| "Stereoselective Synthesis of Nitrogen-ConT.ning Heterocycles via Nickel-Catalyzed Cyclization of 1,3-Diene and Aldehyde: Formal Total Synthesis of (-)-Elaeokanine C" | |
| Tetrahedron 1998, 54 (7), 1153-1168. [DOI] | |
| 1. | Yoshihiro Sato, Nozomi Saito, Miwako Mori |
| Efficient Synthesis of Pyrrolizidine and Indolizidine Derivatives Using Nickel-Catalyzed Cyclization of 1,3-Diene and Aldehyde: Formal Total Synthesis of (-)-Elaeokanine C" | |
| Tetrahedron Lett. 1997, 38 (22), 3931-3934. [DOI] |
総説・紀要
| 13. | 齋藤 望、佐藤美洋 |
| 「遷移金属錯体を利用したイナミドの新規分子変換反応の開発と応用研究」 | |
| 有機合成化学協会誌 2018, 76 (7), 699-709. [DOI] | |
| 12. | Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Hiroshi Saito, Shinji Kakuda, Midori Takimoto-Kamimura, |
| Kazuya Takenouchi, Atsushi Kittaka | |
| "The Difference between 14-Epi-previtamin D3 and 14-Epi-19-norprevitamin D3: Their Synthesis and Binding Affinity for Human VDR" | |
| Anticancer Res. 2012, 32 (1), 319-326. [DOI] | |
| 11. | Go Kumagai, Masashi Takano, Kanako Shindo, Daisuke Sawada, Nozomi Saito, Hiroshi Saito, Shinji Kakuda, Ken-ichi Takagi, |
| Midori Takimoto-Kamimura, Kazuya Takenouchi, Tai C. Chen, Atsushi Kittaka | |
| "C15-functionalized 16-Ene-1α,25-dihydroxyvitamin D3 is a New Vitamin D Analog with Unique Biological Properties" | |
| Anticancer Res. 2012, 32 (1), 311-318. [DOI] | |
| 10. | Nozomi Saito, Daisuke Tanaka, Miwako Mori, Yoshihiro Sato |
| "Ruthenium-Catalyzed Cyclizations of Enynes via a Ruthenacyclopentene Intermediate ~Development of Three Novel Cyclizations Controlled by a Substituent on Alkyne of Enyne~" | |
| Chem. Rec. 2011,11 (4), 186-198. [DOI] | |
| 9. | 齋藤 望、森美和子、佐藤美洋 |
| 「ルテナシクロペンテン中間体を経由するエンインの新規環化反応の開発」 | |
| 有機合成化学協会誌 2010, 68 (4), 348-358. [DOI] | |
| 8. | 橘高敦史、 齋藤 望、 竹之内一弥、 石塚誠一 |
| 「TEI-9647とTEI-9648の構造活性相関研究：2α位と24位の化学修飾 ～最強のVDRアンタゴニスト活性を目指して～」 | |
| ビタミン 2009, 38 (10), 569-579. | |
| 7. | 齋藤 望、橘高敦史 |
| 「ビタミンD3-26,23-ラクトンを基盤とするビタミン D 受容体アンタゴニストの設計と合成」 | |
| 有機合成化学協会誌 2007, 65 (10), 947-958. [DOI] | |
| 6. | 齋藤 望 |
| 「強力なビタミンD受容体アンタゴニストの創製に関する研究」 | |
| 薬学雑誌 2007, 127 (8), 1215-1222. | |
| 5. | Atsushi Kittaka, Nozomi Saito, Shinobu Honzawa, Kazuya Takenouchi, Seiichi Ishizuka, Tai C. Chen, Sara Peleg, Sigeaki Kato, Midori A. Arai |
| "Creative Synthesis of Novel Vitamin D Analogs for Health and Disease" | |
| J. Steroid Biochem. Mol. Biol. 2007, 133 (3-5), 269-276. | |
| 4. | Nozomi Saito, Atsushi Kittaka |
| "Highly Potent Vitamin D Antagonists: Design, Synthesis and Biological Evaluation" | |
| ChemBioChem 2006, 7 (10), 1478-1490. [DOI] | |
| 3. | Nozomi Saito, Shinobu Honzawa, Atsushi Kittaka |
| "Recent results on A-ring modification of 1α,25-dihydroxyvitamin D3: Design and synthesis of VDR-agonists and antagonists with high biological activity" | |
| Curr. Top. Med. Chem. 2006, 6 (12), 1273-1288. | |
| 2. | 橘髙敦史、齋藤 望、高野真史 |
| 「ビタミンD誘導体研究の最近の進歩（１）～セコステロイド骨格の多様性と生物活性～」 | |
| Clinical Calcium 2006, 16 (7), 70-81. | |
| 1. | Toshie Fujishima, Atsushi Kittaka, Masaaki Kurihara, Nozomi Saito, Shinobu Honzawa, Seichi Kishimoto, Takayuki Sugiura, |
| Keizo Waku, Hiroaki Takayama | |
| "2,2-Functionalized analogues of 1α,25-dihydroxyvitamin D3, the potent inducers of cell differentiation" | |
| J. Steroid Biochem. Mol. Biol. 2004, 89-90, 89-92. |
